Troxerutin is a derivative of the natural bioflavonoid rutin. Troxerutin is found in many plants, and can be easily extracted from Sophora japonica (Japanese pagoda tree). Troxerutin is best suited for the treatment of the varicose syndrome, varicose ulcers, thrombophlebitis, and chronic venous deficiency. Troxerutin can also be successfully applied for muscle pain and edemas due to traumatic vein blood-flow disorders.